Adrenal Cancer: Symptoms, Causes, Diagnosis, and Treatment Options Explained

What is Adrenal Cancer?

Adrenal cancer is a rare disease that starts in the adrenal glands. These glands sit above each kidney. They make hormones that help control blood pressure, stress, and other body functions. When a tumor grows in an adrenal gland, it can be cancerous or non-cancerous. However, adrenal cancer means the tumor is malignant and can spread to other parts of the body. Early detection is important for better outcomes. According to the American Cancer Society, adrenal cancer affects only a small number of people each year.

Symptoms of Adrenal Cancer

Adrenal cancer symptoms can vary. Sometimes, people do not notice signs right away. Yet, as the tumor grows, symptoms may appear. For example, some tumors make extra hormones, which can cause changes in the body. Others may not make hormones but still cause problems as they get larger.

  • Unexplained weight gain or loss
  • Muscle weakness
  • High blood pressure that is hard to control
  • Excess hair growth, especially in women
  • Deepening of the voice
  • Abdominal pain or a lump in the belly
  • Easy bruising
  • Changes in mood or energy
  • Because these symptoms can look like other health problems, it is important to see a doctor if you notice any changes.

    Causes and Risk Factors

    Doctors do not know the exact cause of adrenal cancer. Still, some risk factors may increase the chance of developing this disease. For instance, certain inherited conditions can raise the risk. Although most cases happen by chance, knowing the risk factors can help you stay aware.

  • Family history of adrenal cancer or related genetic syndromes
  • Conditions like Li-Fraumeni syndrome or Beckwith-Wiedemann syndrome
  • Multiple endocrine neoplasia type 1 (MEN1)
  • Being between 40 and 50 years old
  • Having a history of other rare tumors
  • Even though these risk factors exist, many people with adrenal cancer have no known risks. Therefore, regular check-ups are important, especially if you have a family history.

    How Adrenal Cancer is Diagnosed

    Doctors use several steps to diagnose an adrenal gland tumor. First, they will ask about your symptoms and medical history. Next, they may order blood and urine tests to check hormone levels. These tests can show if the tumor is making extra hormones. In addition, imaging tests help doctors see the tumor and check if it has spread.

  • CT scans or MRI scans to get clear pictures of the adrenal glands
  • Blood and urine tests for hormone levels
  • Biopsy, where a small piece of tissue is taken and checked under a microscope
  • Because adrenal cancer is rare, doctors may also consult with specialists. Early and accurate adrenal gland tumor diagnosis helps guide the best treatment plan.

    Treatment Options for Adrenal Cancer

    Treatment for adrenal cancer depends on the size and stage of the tumor. It also depends on your overall health. Most often, surgery is the main treatment. Removing the adrenal gland with the tumor can help stop the spread. In some cases, other treatments may be needed.

  • Surgery to remove the affected adrenal gland
  • Chemotherapy to kill cancer cells
  • Radiation therapy to shrink tumors or relieve symptoms
  • Medications to block hormone production
  • Sometimes, doctors use a mix of these adrenal cancer treatment options. After treatment, regular follow-up visits are important to watch for any signs of the cancer coming back.

    Prevention and Lifestyle Guidance

    Currently, there is no sure way to prevent adrenal cancer. However, knowing your family history can help. If you have a genetic risk, your doctor may suggest regular screening. In addition, healthy habits support your overall well-being.

  • Eat a balanced diet with plenty of fruits and vegetables
  • Stay active with regular exercise
  • Avoid smoking and limit alcohol
  • Manage stress with relaxation techniques
  • See your doctor for regular check-ups, especially if you have risk factors
  • While these steps cannot guarantee prevention, they can help you stay as healthy as possible. For more information, you can visit trusted sources like the Centers for Disease Control and Prevention (CDC) or the World Health Organization (WHO).